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客座教授-Mattias Mannervik
2017-06-06 10:10     (点击: )


Stockholm University

Department of Molecular Biosciences, the Wenner-Gren Institute

Arrheniuslaboratories E3, SE-106 91 Stockholm, Sweden

e-mail: mattias.mannervik@su.se, Tel: +46-8-161565

 Born in Stockholm, Sweden, August 16th 1967.


Professional preparation


Undergraduate University: Stockholm University. Bachelor of Science in Chemistry and Microbiology, 1991

Graduate University: Uppsala University, Dept. of Medical Immunology & Microbiology. Area of molecular biology. Doctor of Medical Science, November 10, 1997

Thesis: Transcriptional regulation by adenovirus early region 1 and 4 proteins. Supervisor: Prof. Göran Akusjärvi 

Postdoc University:  University of California, Berkeley, Dept. of Molecular & Cell Biology, Division of Genetics and Development. Area of developmental biology, Jan. 1998 – Nov. 1999 Supervisor: Prof. Mike Levine

Docent (Associate Professor): Docent i zoologisk utvecklingsbiologi, Stockholms Universitet, 2004-03-11.



Professor of Molecular developmental biology at Stockholm University since 2011-12-01 Director of studies in developmental biology

Previous positions 

Lecturer in molecular developmental biology at Stockholm University, 2011-01-01 – 2011-11-30

Researcher (Associate professor) in zoological developmental biology at Stockholm University, 2004-05-01 – 2010-12-31

Assistant Professor at Stockholm University funded by the Swedish Research Council,

2000-05-01 – 2004-04-30.  


External examiner (Opponent) at doctoral disputations 4 times

Member of doctoral examination board ~20 times

Reviewer on Assistant Professor appointment in hematology and epigenomics, and on Associate Professor appointment in molecular cell biology (both at Karolinska Institute)Ad hoc reviewer of NSF (USA), FRM (France) and Swedish Cancer Society grants 

I have served as a referee for the journals PLoS Biology, PNAS, Cell Reports, Current Biology, PLoS Genetics, Development, Develomental Biology, Molecular and Cellular Biology (MCB), Nucleic Acids Research (NAR), PLoS One, Mechanisms of Development, Chromosoma, Molecular Genetics and Genomics, Developmental Dynamics, and FEBS Letters.

List of Publications

 Mannervik M., P. Putkonen, U. Ruden, K. Kent, E. Norrby, B. Wahren and P.A. Broliden (1992). Identification of B-cell antigenic sites on HIV-2 gp125. J. AIDS 5, 177-187.  

Bondesson M., M. Mannervik, G. Akusjärvi and C. Svensson (1994). An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter. Nucleic Acids Res. 22, 3053-3060. 

Bondesson M., K. Öhman, M. Mannervik, S. Fan and G. Akusjärvi (1996). Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter. J. Virol. 70, 3844-3851.  

Jordan P., M. Mannervik, L. Tora and M. Carmo-Fonseca (1996). In vivo evidence that TATA-binding protein SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive. J. Cell. Biol. 133, 225-234.  

Mannervik M.  and G. Akusjärvi (1997). The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation independent of a direct interaction. FEBS Lett. 414, 111-116. 

Mannervik M., S. Fan, A.-C. Ström, K. Helin and G. Akusjärvi (1999). Adenovirus E4-ORF4 induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1 mediated transactivation independently of the retinoblastoma tumor suppressor protein. Virology 256, 313-321.

Mannervik M.  (1999). Target genes of homeodomain  proteins. BioEssays 21, 267-270.  

Mannervik M., Y. Nibu, H. Zhang and M. Levine (1999). Transcriptional coregulators in development. Science 284, 606-609.

Mannervik M. and M. Levine (1999). The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo. Proc. Natl. Acad. Sci. U.S.A. 96, 6797-6801.  

Ashe H., M. Mannervik and M. Levine (2000). Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo. Development 127, 3305-3312.

Mannervik M. (2001). Corepressor proteins in Drosophila development. Current Topics in Microbiology and Immunology 254, 79-100. 

Oron E., M. Mannervik, S. Rencus, O. Harari-Steinberg, S.L. Zipursky, S. Neuman-Silberberg, D. Segal and D.A. Chamovitz (2002). COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. Development 129, 4399-4409. 

Lilja T., Q. Dai, M. Stabell and M. Mannervik (2003). The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo. Dev. Biol. 262, 294-302. 

Dai Q., Larsson J. and M. Mannervik. (2004) Drosophila Ada2b is required for viability and normal histone H3 acetylation. Mol. Cell. Biol., 24, 8080-8089. 

Dai Q., Jin H., T. Lilja and M. Mannervik (2006). Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. Genetics 174, 241-251 

Lilja T., H. Aihara, M. Stabell, Y. Nibu and M. Mannervik (2007). The acetyltransferase activity of Drosophila CBP is dispensable for regulation of the Dpp pathway in the early embryo. Dev. Biol., 305, 650-658. 

Haecker A., Dai Q., Lilja T., Moussian B., Andrioli LP., Luschnig S., and M. Mannervik (2007). Drosophila Brakeless Interacts with Atrophin and is Required for Tailless-Mediated Transcriptional Repression in Early Embryos. PLoS Biology, 5, 1298-1308.

 Dai Q. M. Bergman, H. Aihara, Y. Nibu and M. Mannervik (2008). Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation. EMBO J, 27, 898-909.

 Haecker A., Bergman M., Neupert C., Moussian B., Luschnig S., Aebi M., and M. Mannervik (2008). Wollknäuel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase. Development, 135, 1745-1749. 

Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP (2011). A cis-regulatory map of the Drosophila genome. Nature, 471, 527-31.  

Melas PA, Mannervik M, Mathé AA, Lavebratt C (2012). Neuropeptide Y: Identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. Peptides, 35, 49-55. 

Holmqvist PH, Boija A, Philip P, Crona F, Stenberg P, and M. Mannervik (2012). Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. PLoS Genetics, 8(6):e1002769 

Holmqvist PH and M. Mannervik (2013). Genomic occupancy of the transcriptional co-activators p300 and CBP. Transcription, 4(1), 18-23. 

Melas PA, Lennartsson A, Vakifahmetoglu-Norberg H, Wei Y, Åberg E, Werme M, Rogdaki M, Mannervik M, Wegener G, Brené S, Mathé AA, Lavebratt C. (2013) Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression. Transl Psychiatry, 3:e255 

Crona F, Dahlberg O, Lundberg LE, Larsson J, and M. Mannervik (2013) Gene regulation by the lysine demethylase KDM4A in Drosophila. Dev Biol., 373, 453-63.

Mannervik M. (2014) Control of Drosophila embryo patterning by transcriptional co-regulators.

Exp Cell Res. 321(1):47-57

 Mazari AM, Dahlberg O, Mannervik B, and M. Mannervik (2014). Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in males and females. PLoS One, 9(10):e110103.

Dahlberg O, Shilkova O, Tang M, Holmqvist PH, and M. Mannervik (2015) P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development. PLoS Genet. 11(2):e1004971. 

Shir-Shapira H, Sharabany J, Filderman M, Ideses D, Ovadia-Shochat A, Mannervik M, Juven-Gershon T. (2015) Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential Activation. J Biol Chem. 290(28):17293-305. 

Crona F, Holmqvist PH, Tang M, Singla B, Vakifahmetoglu-Norberg H, Fantur K, Mannervik M. (2015) The Brakeless co-regulator can directly activate and repress transcription in early Drosophila embryos. Dev Biol. Aug 7:DBIO15182.

Boija A and Mannervik M.(2015) A time of change: Dynamics of chromatin and transcriptional regulation during nuclear programming in early Drosophila development. Mol Reprod Dev. 82:735-46 

Crona F, Singla B, Mannervik M. (2015) Gene expression profiling of brakeless mutant Drosophila embryos. Data Brief. 5:134-7

Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P. (2015) CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics & Chromatin. 8:48. 

Boija A, Mannervik M. (2016) Initiation of diverse epigenetic states during nuclear programming of the Drosophila body plan. Proc Natl Acad Sci U S A. 113:8735-40.

Derkacheva M, Liu S, Figueiredo DD, Gentry M, Mozgova I, Nanni P, Tang M, Mannervik M, Köhler C, Hennig L. (2016) H2A deubiquitinases UBP12/13 are part of the Arabidopsis polycomb group protein system. Nature Plants. 2:16126.


Stockholm University

Department of Molecular Biosciences, the Wenner-Gren Institute

Arrheniuslaboratories E3, SE-106 91 Stockholm, Sweden

e-mail: mattias.mannervik@su.se, Tel: +46-8-161565






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